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Publications

• Erickson BA, Griffith JW, Wensheng G, Mengying Y, Herman T, Bradley CS, Quentin Clemens J, Farrar JT, Gupta P, Kreder KJ, Henry Lai H, Naliboff BD, Newman DK, Rodriguez LV, Spitznagle T, Sutcliffe S, Sutherland SE, Taple BJ, Richard Landis J.  Ecological Momentary Assessment of Pelvic Pain and Urinary Urgency Variability in Urologic Chronic Pelvic Pain Syndrome and Their Association with Illness Impact and Quality of Life: Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study. Neurourol Urodyn. 2024 Apr;43(4):893-901. doi: 10.1002/nau.25363. Epub 2024 Jan 22. [PMID: 38247366] [PMC11031348]
  Keywords: ecological momentary assessment; illness impact; phone application; quality of life; urologic chronic pelvic pain syndrome; variability.

• Brown VL, James A, Hunleth J, Bradley CS, Farrar JT, Gupta P, Lai HH, Lowder JL, Moldwin R, Rodriguez LV, Yang CC, Sutcliffe S. Believing Women: A Qualitative Exploration of Provider Disbelief and Pain Dismissal among Women with Interstitial Cystitis/Bladder Pain Syndrome from the MAPP Research Network. Int Urogynecol J. 2024 Jan;35(1):139-148. doi: 10.1007/s00192-023-05677-0. Epub 2023 Nov 22. [PMID: 37991567] [PMC11019919]
  Keywords: Chronic pain; Delayed diagnosis; Interstitial cystitis; Patient–provider encounter; Qualitative; Women.

• Schrepf AD, Mawla I, Naliboff BD, Gallop B, Moldwin RM, Tu F, Gupta P, Harte S, Krieger JN, Yang C, Bradley C, Rodriguez L, Williams D, Magnotta V, Ichesco E, Harris RE, Clemens Q, Mullins C, Kutch JJ. Neurobiology and long-term impact of bladder-filling pain in humans: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) research network study. Pain. 2023 Oct 1;164(10):2343-2351. doi: 10.1097/j.pain.0000000000002944. Epub 2023 Jun 6. PMID: 37278657 [PMID: 37278657] [PMC10524087]
  Keywords: Chronic pain, Bladder, Urology, Resting-state, fMRI, Flare-up, Healthcare utilization.
• Pierce J, Harte SE, Afari N, Bradley CS, Griffith JW, Kim J, Lutgendorf S, Naliboff BD, Rodriguez LV, Taple BJ, Williams D, Harris RE, Schrepf A; MAPP Research Network. Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis. Pain. 2023 Sep 1;164(9):1995-2008. doi: 10.1097/j.pain.0000000000002895. Epub 2023 May 5. [PMID: 37144687] [PMC10440258]
  Keywords: Trauma, Childhood abuse, Pain sensitivity, Quantitative sensory testing.
• Lutgendorf SK, Zia S, Luo Y, O'Donnell M, van Bokhoven A, Bradley CS, Gallup R, Pierce J, Taple BJ, Naliboff BD, Quentin Clemens J, Kreder KJ, Schrepf A. Early and Recent Exposure to Adversity, TLR-4 Stimulated Inflammation, and Diurnal Cortisol in Women with Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Research Network Study. Brain Behav Immun. 2023 Jul;111:116-123. doi: 10.1016/j.bbi.2023.03.024. Epub 2023 Mar 29. [PMID: 37001828] [PMC10474614]
  Keywords: Chronic stress; Cortisol; Early life adversity; HPA axis; IC/BPS; Inflammation; Interstitial cystitis; Pain; Recent life adversity.
• Stephens-Shields AJ, Lai HH, Landis JR, Kreder K, Rodriguez LV, Naliboff BD, Afari N, Sutcliffe S, Moldwin R, Griffith JW, Clemens JQ, Bradley CS, Quallich S, Gupta P, Harte SE, Farrar JT. Clinically Important Differences for Pain and Urinary Symptoms in Urological Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol. 2023 Jun;209(6):1132-1140. doi: 10.1097/JU.0000000000003394. Epub 2023 Feb 27. [PMID: 36848118] [PMC11062515]
  Keywords: cystitis, interstitial; minimal clinically important difference; pelvic pain; research design; treatment outcome.
• Schrepf A, Kaplan C, Harris RE, Williams DA, Clauw DJ, As-Sanie S, Till S, Clemens JQ, Rodriguez LV, Van Bokhoven A, Landis R, Gallop R, Bradley C, Naliboff B, Pontari M, O'Donnell M, Luo Y, Kreder K, Lutgendorf SK, Harte SE. Stimulated whole-blood cytokine/chemokine responses are associated with interstitial cystitis/bladder pain syndrome phenotypes and features of nociplastic pain: a multidisciplinary approach to the study of chronic pelvic pain research network study. Pain. 2023 May 1;164(5):1148-1157. doi: 10.1097/j.pain.0000000000002813. [PMID: 36279178] [PMC10106356]
  Keywords: Chronic pain; Interstitial cystitis/bladder pain syndrome; toll-like receptor.
• Sutcliffe S, Newcomb C, Bradley CS, Clemens JQ, Erickson B, Gupta P, Lai HH, Naliboff B, Strachan E, Stephens-Shields A. Associations Between Urological Chronic Pelvic Pain Syndrome Symptom Flares, Illness Impact, and Health Care Seeking Activity: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study. J Urol. 2023 Apr 1;209(4):719-725. doi: 10.1097/JU.0000000000003155. Epub 2023 Jan 11. [PMID: 36630590] [PMC10333444]
  Keywords: cystitis, interstitial; prostatitis; symptom flare up.
• Bradley CS , Gallop R , Sutcliffe S, Kreder KJ, Lai HH, Clemens JQ, Naliboff BD, for the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Long-term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study. Urology. 2022 Nov;169:58-64. doi: 10.1016/j.urology.2022.07.045. Epub 2022 Aug 9. [PMID: 35961564] [PMC10590538]
  Keywords: Chronic prostatitis; extended follow-up; interstitial cystitis; MAPP network cohort study; urologic chronic pelvic pain syndrome; bladder pain syndrome.
• Gupta P, Gallop R, Spitznagle T, Lai H, Tu F, Krieger JN, Clemens JQ, Bradley CS, Yang C, Sutcliffe S, Moldwin R, Kreder K, Kutch J, Rodriguez LV. Is Pelvic Floor Muscle Tenderness a Distinct Urologic Chronic Pelvic Pain Syndrome Phenotype? Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Symptom Pattern Study. J Urol. 2022 Aug;208(2):341-349. doi: 10.1097/JU.0000000000002679. Epub 2022 Mar 28. [PMID: 35344391] [PMC10123541]
  Keywords: chronic prostatitis with chronic pelvic pain syndrome; cystitis; interstitial; pelvic pain.
• Clemens JQ, Stephens-Shields AJ, Newcomb C, Rodriguez LV, Lai HH, Bradley CS, Naliboff BD, Griffith JW, Taple BJ, Gupta P, Afari N, Harte SE, Strachan E, Guo W, Landis JR. Correlates of 1-year change in quality of life in patients with urologic chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. J Urol. 2020 Oct;204(4):754-759. doi: 10.1097/JU.0000000000001080. Epub 2020 Apr 15. [PMID: 32294397] [PMC7483873]
  Keywords: cystitis; interstitial; prostatitis.
• Xu T, Lai HH, Pakpahan R, Vetter J, Andriole GL, Bradley C, Naliboff BD, Colditz GA, Sutcliffe S. Changes in whole body pain intensity and widespreadness during urologic chronic pelvic pain syndrome flares-Findings from one site of the MAPP study. Neurourol Urodyn. 2019 Nov;38(8):2333-2350. doi: 10.1002/nau.24150. Epub 2019 Sep 4. [PMID: 31483064] [PMC9188843]
  Keywords: chronic prostatitis; flares; interstitial cystitis; longitudinal study; symptom exacerbations.
• Sutcliffe S, Gallop R, Henry Lai HH, Andriole GL, Bradley CS, Chelimsky G, Chelimsky T, Quentin Clemens J, Colditz GA, Erickson B, Griffith JW, Kim J, Krieger JN, Labus J, Naliboff BD, Rodriguez LV, Sutherland SE, Taple BJ, Landis JR. A longitudinal analysis of urological chronic pelvic pain syndrome flares in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int. 2019 Sep;124(3):522-531. doi: 10.1111/bju.14783. Epub 2019 May 29. [PMID: 31012513] [PMC6706296]
  Keywords: epidemiology; interstitial cystitis; prostatitis; symptom flare-up.
• Cui X, Jing X, Lutgendorf SK, Bradley CS, Schrepf A, Erickson BA, Magnotta VA, Ness TJ, Kreder KJ, O'Donnell MA, Luo Y. Cystitis-induced bladder pain is Toll-like receptor 4 dependent in a transgenic autoimmune cystitis murine model: a MAPP Research Network animal study. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F90-F98. doi: 10.1152/ajprenal.00017.2019. Epub 2019 May 15. [PMID: 31091120] [PMC6692719]
  Keywords: Toll-like receptor 4; cystitis; model; pain.
• Rodríguez LV, Stephens AJ, Clemens JQ, Buchwald D, Yang C, Lai HH, Krieger JN, Newcomb C, Bradley CS, Naliboff B; MAPP Research Network. Symptom duration in patients with urologic chronic pelvic pain syndrome is not associated with pain severity, nonurologic syndromes and mental health symptoms: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Network Study. Urology. 2019 Feb;124:14-22. doi: 10.1016/j.urology.2018.11.015. Epub 2018 Nov 16. [PMID: 30452963] [PMC7037673]
  Keywords: chronic pain; mental disorders; pain measurement; pelvic pain; severity of illness index; symptom assessment.
• Schrepf A, Naliboff B, Williams DA, Stephens-Shields AJ, Landis JR, Gupta A, Mayer E, Rodriguez LV, Lai H, Luo Y, Bradley C, Kreder K, Lutgendorf SK; MAPP Research Network. Adverse childhood experiences and symptoms of urologic chronic pelvic pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med. 2018 Sep 13;52(10):865-877. doi: 10.1093/abm/kax060. [PMID: 30212850] [PMC6135957]
  Keywords: Interstitial Cystitis/Painful Bladder Syndrome; Chronic Prostatitis with Chronic Pelvic Pain Syndrome; Psychological Trauma; Sexual Abuse.
• Sutcliffe S, Jemielita T, Lai HH, Andriole GL, Bradley CS, Clemens JQ, Gallop R, Hooton TM, Kreder KJ, Krieger JN, Kusek JW, Labus J, Lucia MS, Mackey S, Naliboff BD, Robinson NA, Rodriguez LV, Stephens-Shields A, van Bokhoven A, Wolin KY, Yan Y, Yang CC, Landis JR, Colditz GA; MAPP Research Network. A case-crossover study of urological chronic pelvic pain syndrome flare triggers in the MAPP Research Network. J Urol. 2018 May;199(5):1245-1251. doi: 10.1016/j.juro.2017.12.050. Epub 2017 Dec 27. [PMID: 29288643] [PMC5911194]
  Keywords: cystitis; interstitial; prostatitis; surveys and questionnaires; symptom flare up; urinary bladder.
• Kogan P, Xu S, Wang Y, O'Donnell MA, Lutgendorf SK, Bradley CS, Schrepf A, Kreder KJ, Luo Y. Sub-noxious Intravesical lipopolysaccharide triggers bladder inflammation and symptom onset in a transgenic autoimmune cystitis model: A MAPP Network Animal Study. Sci Rep. 2018 Apr 26;8(1):6573. doi: 10.1038/s41598-018-24833-x. [PMID: 29700406] [PMC5919907]
  Keywords: autoimmunity; experimental models of disease.
• Lai HH, Jemielita T, Sutcliffe S, Bradley CS, Naliboff B, Williams DA, Gereau RW 4th, Kreder K, Clemens JQ, Rodriguez LV, Krieger JN, Farrar JT, Robinson N, Landis JR; MAPP Research Network. Characterization of whole-body pain in urological chronic pelvic pain syndrome at baseline: A MAPP Research Network Study. J Urol. 2017 Sep;198(3):622-631. doi: 10.1016/j.juro.2017.03.132. Epub 2017 Mar 31. [PMID: 28373134] [PMC5562525]
  Keywords: cystitis; interstitial; pelvic pain; prostate; prostatitis; urinary bladder.
• Wang X, Liu W, O'Donnell M, Lutgendorf S, Bradley C, Schrepf A, Liu L, Kreder K, Luo Y. Evidence for the role of mast cells in cystitis-associated lower urinary tract dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study. PLoS One. 2016 Dec 21;11(12):e0168772. doi: 10.1371/journal.pone.0168772. eCollection 2016. [PMID: 28002455] [PMC5176179]
  Category: Mast cells; Bladder; Cystitis; Mouse models; Inflammation; Urination; Habits; Pain.
• Xu S, Wang X, Wang Y, Lutgendorf S, Bradley C, Schrepf A, Kreder K, O'Donnell M, Luo Y. Transgenic mice expressing mcp-1 by the urothelium demonstrate bladder hypersensitivity, pelvic pain and voiding dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study. PLoS One. 2016 Sep 29;11(9):e0163829. doi: 10.1371/journal.pone.0163829. eCollection 2016. [PMID: 27684718] [PMC5042429]
  Keywords: Bladder; Mouse models; Inflammation; Pain; Genetically modified animals; Cystitis; Habits; Urination.
• Griffith JW, Stephens-Shields AJ, Hou X, Naliboff BD, Pontari M, Edwards TC, Williams DA, Clemens JQ, Afari N, Tu F, Lloyd RB, Patrick DL, Mullins C, Kusek JW, Sutcliffe S, Hong BA, Lai HH, Krieger JN, Bradley CS, Kim J, Landis JR. Pain and urinary symptoms should not be combined into a single score: psychometric findings from the MAPP Research Network. J Urol. 2016 Apr;195(4 Pt 1):949-54. doi: 10.1016/j.juro.2015.11.012. Epub 2015 Nov 14. [PMID: 26585679] [PMC4867140]
  Keywords: chronic pain; cystitis, interstitial; factor analysis, statistical; prostatitis; urinary bladder.
• Schrepf A, O'Donnell MA, Luo Y, Bradley CS, Kreder KJ, Lutgendorf SK. Inflammation and symptom change in interstitial cystitis or bladder pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Urology. 2016 Apr;90:56-61. doi: 10.1016/j.urology.2015.12.040. Epub 2016 Jan 6. [PMID: 26768711] [PMC4892365]
  Keywords: Interstitial Cystitis, Inflammation, Toll-Like Receptor 2, Toll-Like Receptor 4, Hydrocortisone
• Schrepf A, Bradley CS, O'Donnell M, Luo Y, Harte SE, Kreder K, Lutgendorf S; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Toll-like receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study. Brain Behav Immun. 2015 Oct;49:66-74. doi: 10.1016/j.bbi.2015.03.003. Epub 2015 Mar 11. [PMID: 25771510] [PMC4567436]
  Keywords: Functional somatic syndromes; Inflammation; Interstitial Cystitis/Bladder Pain Syndrome; Negative affect; Pain; Toll-like Receptors.
• Sutcliffe S, Bradley CS, Clemens JQ, James AS, Konkle KS, Kreder KJ, Lai HH, Mackey SC, Ashe-McNalley CP, Rodriguez LV, Barrell E, Hou X, Robinson NA, Mullins C, Berry SH. Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network. Int Urogynecol J. 2015 Jul;26(7):1047-60. doi: 10.1007/s00192-015-2652-6. Epub 2015 Mar 20. [PMID: 25792349] [PMC4489981]
  Keywords: Urological chronic pelvic pain syndrome; Interstitial cystitis; Bladder pain syndrome; Symptom exacerbation; Flare; Focus group.
• Sutcliffe S, Colditz GA, Pakpahan R, Bradley CS, Goodman MS, Andriole GL, Lai HH. Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: findings from one site of the MAPP Research Network. Neurourol Urodyn. 2015 Feb;34(2):188-95. doi: 10.1002/nau.22534. Epub 2013 Nov 23. [PMID: 24273163] [PMC4032370]
  Keywords: bladder pain syndrome; chronic pelvic pain syndrome; chronic prostatitis; flare; interstitial cystitis; symptom exacerbation.
• Schrepf A, O'Donnell M, Luo Y, Bradley CS, Kreder K, Lutgendorf S; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms. Pain. 2014 Sep;155(9):1755-1761. doi: 10.1016/j.pain.2014.05.029. Epub 2014 Jun 5. [PMID: 24907404] [PMC4166494]
  Keywords: Bladder pain syndrome; Hypothalamic–pituitary–adrenal axis; Inflammation; Interstitial cystitis; Pelvic pain; Toll-like receptors.
• Landis JR, Williams DA, Lucia MS, Clauw DJ, Naliboff BD, Robinson NA, van Bokhoven A, Sutcliffe S, Schaeffer AJ, Rodriguez LV, Mayer EA, Lai HH, Krieger JN, Kreder KJ, Afari N, Andriole GL, Bradley CS, Griffith JW, Klumpp DJ, Hong BA, Lutgendorf SK, Buchwald D, Yang CC, Mackey S, Pontari MA, Hanno P, Kusek JW, Mullins C, Clemens JQ; MAPP Research Network Study Group. The MAPP research network: design, patient characterization and operations. BMC Urol. 2014 Aug 1;14:58. doi: 10.1186/1471-2490-14-58. [PMID: 25085119] [PMC4126395]
  Keywords: Urologic chronic pelvic pain syndromes; Interstitial cystitis; Chronic prostatitis; Urine biomarkers; Plasma biomarkers; Non-urologic associated syndromes; Quantitative sensory testing (QST); Neuroimaging.