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Publications

• Schrepf AD, Mawla I, Naliboff BD, Gallop B, Moldwin RM, Tu F, Gupta P, Harte S, Krieger JN, Yang C, Bradley C, Rodriguez L, Williams D, Magnotta V, Ichesco E, Harris RE, Clemens Q, Mullins C, Kutch JJ. Neurobiology and long-term impact of bladder-filling pain in humans: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) research network study. Pain. 2023 Oct 1;164(10):2343-2351. doi: 10.1097/j.pain.0000000000002944. Epub 2023 Jun 6. PMID: 37278657 [PMID: 37278657] [PMC10524087]
  Keywords: Chronic pain, Bladder, Urology, Resting-state, fMRI, Flare-up, Healthcare utilization.
• Wang C, Kutch JJ, Labus JS, Yang CC, Harris RE, Mayer EA, Ellingson BM. Reproducible Microstructural Changes in the Brain Associated With the Presence and Severity of Urologic Chronic Pelvic Pain Syndrome (UCPPS): A 3-Year Longitudinal Diffusion Tensor Imaging Study From the MAPP Network. J Pain. 2023 Apr;24(4):627-642. doi: 10.1016/j.jpain.2022.11.008. Epub 2022 Nov 23. [PMID: 36435486] [PMC10676766]
  Keywords: Urological chronic pelvic pain; UCPPS; Longitudinal observation; Diffusion tensor imaging; Probabilistic tractography.
• Gupta P, Gallop R, Spitznagle T, Lai H, Tu F, Krieger JN, Clemens JQ, Bradley CS, Yang C, Sutcliffe S, Moldwin R, Kreder K, Kutch J, Rodriguez LV. Is Pelvic Floor Muscle Tenderness a Distinct Urologic Chronic Pelvic Pain Syndrome Phenotype? Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Symptom Pattern Study. J Urol. 2022 Aug;208(2):341-349. doi: 10.1097/JU.0000000000002679. Epub 2022 Mar 28. [PMID: 35344391] [PMC10123541]
  Keywords: chronic prostatitis with chronic pelvic pain syndrome; cystitis; interstitial; pelvic pain.
• Deutsch G, Deshpande H, Lai HH, Kutch JJ, Ness TJ. Cerebral Perfusion and Sensory Testing Results Differ in Interstitial Cystitis/Bladder Pain Syndrome Patients with and without Fibromyalgia: A Site-Specific MAPP Network Study.  J Pain Res. 2021 Dec 23;14:3887-3895. doi: 10.2147/JPR.S343695. eCollection 2021.  [PMID: 34992450] [PMC8711634]
  Keywords: QST; arterial spin labelling; fMRI; interstitial cystitis.
• Mawla I, Schrepf A, Ichesco E, Harte SE, Klumpp DJ, Griffith JW, Strachan E, Yang CC, Lai H, Andriole G, Magnotta VA, Kreder K, Clauw DJ, Harris RE, Clemens JQ, Landis JR, Mullins C, Rodriguez LV, Mayer EA, Kutch JJ. Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study. Sci Rep. 2020 Nov 16;10(1):19901. doi: 10.1038/s41598-020-76857-x. [PMID: 33199816] [PMC7669903]
  Keywords: bladder; functional magnetic resonance imaging.
• Clemens JQ, Kutch JJ, Mayer EA, Naliboff BD, Rodriguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Clauw DJ, Harte SE, Schrepf AD, Williams DA, Andriole GL, Lai HH, Buchwald D, Lucia MS, van Bokhoven A, Mackey S, Moldwin RM, Pontari MA, Stephens-Shields AJ, Mullins C, Landis JR. The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS). Neurourol Urodyn. 2020 Aug;39(6):1803-1814. doi: 10.1002/nau.24423. Epub 2020 Jun 23. [PMID: 32578257] [PMC8025696]
  Keywords: chronic; interstitial cystitis; plasma biomarkers; prostatitis; urine biomarkers; urological chronic pelvic pain syndromes.
• Fenske SJ, Bierer D, Chelimsky G, Conant L, Ustine C, Yan K, Chelimsky T, Kutch JJ. Sensitivity of functional connectivity to periaqueductal gray localization, with implications for identifying disease-related changes in chronic visceral pain: A MAPP Research Network neuroimaging study. Neuroimage Clin. 2020;28:102443. doi: 10.1016/j.nicl.2020.102443. Epub 2020 Sep 20. [PMID: 33027702] [PMC7548991]
  Keywords: Brain parcellation; Brainstem; PAG; Resting-state; UCPPS; fMRI.
• Gupta A, Bhatt RR, Naliboff BD, Kutch JJ, Labus JS, Vora PP, Alaverdyan M, Schrepf A, Lutgendorf S, Mayer EA; MAPP Research Network. Impact of early adverse life events and sex on functional brain networks in patients with urological chronic pelvic pain syndrome (UCPPS): A MAPP Research Network study. PLoS One. 2019 Jun 20;14(6):e0217610. doi: 10.1371/journal.pone.0217610. eCollection 2019. [PMID: 31220089] [PMC6586272]
  Keywords: centrality; pain; eigenvectors; neural networks; neuroimaging; caudate nucleus; urology; basal ganglia.
• Clemens JQ, Mullins C, Ackerman AL, Bavendam T, van Bokhoven A, Ellingson BM, Harte SE, Kutch JJ, Lai HH, Martucci KT, Moldwin R, Naliboff BD, Pontari MA, Sutcliffe S, Landis JR; MAPP Research Network Study Group. Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network. Nat Rev Urol. 2019 Mar;16(3):187-200. doi: 10.1038/s41585-018-0135-5. [PMID: 30560936] [PMC6800057]
  Keywords: bladder/bladder disease; Urologic chronic pelvic pain syndromes; chronic pain; prostatitis.
• Woodworth DC, Dagher A, Curatolo A, Sachdev M, Ashe-McNalley C, Naliboff BD, Labus JS, Landis JR, Kutch JJ, Mayer EA, Lee RS, Moses MA, Ellingson BM; MAPP Research Network. Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP Network study. PLoS One. 2018 Dec 5;13(12):e0206807. doi: 10.1371/journal.pone.0206807. eCollection 2018. [PMID: 30517112] [PMC6281196]
  Keywords: Urinary biomarkers; Diffusion tensor imaging; Brainstem; Pain; Urine; Biomarkers; Brain; Neuroimaging.
• Kutch JJ, Ichesco E, Hampson JP, Labus JS, Farmer MA, Martucci KT, Ness TJ, Deutsch G, Apkarian AV, Mackey SC, Klumpp DJ, Schaeffer AJ, Rodriguez LV, Kreder KJ, Buchwald D, Andriole GL, Lai HH, Mullins C, Kusek JW, Landis JR, Mayer EA, Clemens JQ, Clauw DJ, Harris RE; MAPP Research Network. Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain. 2017 Oct;158(10):1979-1991. doi: 10.1097/j.pain.0000000000001001. [PMID: 28692006] [PMC5964335]
  Keywords: Centralized; Chronic; Pain; fMRI; Widespread; Fibromyalgia; Pelvic; VBM; Connectivity.
• Kutch JJ, Labus JS, Harris RE, Martucci KT, Farmer MA, Fenske S, Fling C, Ichesco E, Peltier S, Petre B, Guo W, Hou X, Stephens AJ, Mullins C, Clauw DJ, Mackey SC, Apkarian AV, Landis JR, Mayer EA; MAPP Research Network. Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain. 2017 Jun;158(6):1069-1082. doi: 10.1097/j.pain.0000000000000886. [PMID: 28328579] [PMC5435510]
  Keywords: Neuroimaging; Prediction; Chronic pain; Urologic pain.
• Huang L, Kutch JJ, Ellingson BM, Martucci KT, Harris RE, Clauw DJ, Mackey S, Mayer EA, Schaeffer AJ, Apkarian AV, Farmer MA; MAPP Research Network. Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain. 2016 Dec;157(12):2782-2791. doi: 10.1097/j.pain.0000000000000703. [PMID: 27842046] [PMC5117992]
  Keywords: Pain; Urological; Pelvic; Irritable bowel syndrome; Diffusion tensor imaging.
• Kutch JJ, Tu FF. Altered brain connectivity in dysmenorrhea: pain modulation and the motor cortex. Pain. 2016 Jan;157(1):5-6. doi: 10.1097/j.pain.0000000000000364. [PMID: 26683107] [PMC4941100]
  Keywords: brain; brain mapping; dysmenorrhea; magnetic resonance imaging; motor cortex; Nerve Net; neural pathways.
• Woodworth D, Mayer E, Leu K, Ashe-McNalley C, Naliboff BD, Labus JS, Tillisch K, Kutch JJ, Farmer MA, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Landis JR, Deutsch G, Harris RE, Clauw DJ, Mullins C, Ellingson BM; MAPP Research Network. Unique microstructural changes in the brain associated with urological chronic pelvic pain syndrome (UCPPS) revealed by diffusion tensor MRI, super-resolution track density imaging, and statistical parameter mapping: A MAPP Network Neuroimaging Study. PLoS One. 2015 Oct 13;10(10):e0140250. doi: 10.1371/journal.pone.0140250. eCollection 2015. [PMID: 26460744] [PMC4604194]
  Keywords: Pain; Central nervous system; Corpus callosum; Diffusion tensor imaging; Basal ganglia; Microstructure; Anisotropy; Pain sensation.
• Kutch JJ, Yani MS, Asavasopon S, Kirages DJ, Rana M, Cosand L, Labus JS, Kilpatrick LA, Ashe-McNalley C, Farmer MA, Johnson KA, Ness TJ, Deutsch G, Harris RE, Apkarian AV, Clauw DJ, Mackey SC, Mullins C, Mayer EA. Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study. Neuroimage Clin. 2015 Jun 5;8:493-502. doi: 10.1016/j.nicl.2015.05.013. eCollection 2015. [PMID: 26106574] [PMC4474411]
  Keywords: brain mapping; Brief Pain Inventory; chronic prostatitis; functional magnetic resonance imaging; Functional Neuroimaging; image processing; magnetic resonance imaging; motoneuron; motor control; motor cortex; muscle contraction; nerve cell network; Nerve Net; neuroimaging; nuclear magnetic resonance imaging; pathophysiology; pelvis pain syndrome; posterior insula; prostatitis; resting state network.
• Kilpatrick LA, Kutch JJ, Tillisch K, Naliboff BD, Labus JS, Jiang Z, Farmer MA, Apkarian AV, Mackey S, Martucci KT, Clauw DJ, Harris RE, Deutsch G, Ness TJ, Yang CC, Maravilla K, Mullins C, Mayer EA. Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol. 2014 Sep;192(3):947-55. doi: 10.1016/j.juro.2014.03.093. Epub 2014 Mar 26. [PMID: 24681331] [PMC4432915]
  Keywords: brain mapping; cystitis; interstitial; magnetic resonance imaging; pain; urinary bladder.