People

Stephens-Shields AJ (Stephens-Shields A; Stephens AJ; Stephens A)


Publications

  • Stephens-Shields AJ, Lai HH, Landis JR, Kreder K, Rodriguez LV, Naliboff BD, Afari N, Sutcliffe S, Moldwin R, Griffith JW, Clemens JQ, Bradley CS, Quallich S, Gupta P, Harte SE, Farrar JT. Clinically Important Differences for Pain and Urinary Symptoms in Urological Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol. 2023 Jun;209(6):1132-1140. doi: 10.1097/JU.0000000000003394. Epub 2023 Feb 27. [PMID: 36848118] [PMC11062515]
    Keywords: cystitis, interstitial; minimal clinically important difference; pelvic pain; research design; treatment outcome.
  • Sutcliffe S, Newcomb C, Bradley CS, Clemens JQ, Erickson B, Gupta P, Lai HH, Naliboff B, Strachan E, Stephens-Shields A. Associations Between Urological Chronic Pelvic Pain Syndrome Symptom Flares, Illness Impact, and Health Care Seeking Activity: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study. J Urol. 2023 Apr 1;209(4):719-725. doi: 10.1097/JU.0000000000003155. Epub 2023 Jan 11. [PMID: 36630590] [PMC10333444]
    Keywords: cystitis, interstitial; prostatitis; symptom flare up.
  • Farrar JT, Locke KT Jr., Clemens JQ, Griffith JW, Harte SE, Kirkali Z, Kreder KJ, Krieger JN, Lai HH, Moldwin RM, Mullins C, Naliboff BD, Pontari MA, Rodriguez LV, Schaeffer AJ, Schrepf A, Stephens-Shields A, Sutcliffe S, Taple BJ, Williams DA, Landis JR. Widespread Pain Phenotypes Impact Treatment Efficacy Results in Randomized Clinical Trials for Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Study. Res Sq. 2023 Feb 23;rs.3.rs-2441086. doi: 10.21203/rs.3.rs-2441086/v1. Preprint [PMID: 36865104] [PMC9980200]
    Keywords: Randomized controlled trials; Chronic pain; Epidemiology; Functional clustering.
  • Loh-Doyle JC, Stephens-Shields AJ, Rolston R, Newcomb C, Taple B, Sutcliffe S, Yang CC, Lai H, Rodriguez LV. Predictors of Male Sexual Dysfunction in Urologic Chronic Pelvic Pain Syndrome (UCPPS), Other Chronic Pain Syndromes, and Healthy Controls in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. J Sex Med. 2022 Dec;19(12):1804-1812. doi: 10.1016/j.jsxm.2022.08.196. Epub 2022 Sep 28. [PMID: 36180370] [PMC10916540]
    Keywords: Chronic Pelvic Pain; Chronic Prostatitis; Ejaculatory Dysfunction; Erectile Dysfunction; Sexual Dysfunction.
  • Nickel JC, Stephens A, Ackerman AL, Anger JT, Lai HH, Ehrlich GD. The healthy urinary microbiome in asymptomatic participants in the MAPP Network Study: Relation to gender, age, and menopausal status. Can Urol Assoc J. 2022 Sep;16(9):E448-E454. doi: 10.5489/cuaj.7775. [PMID: 35426787] [PMC9484748]
    Keywords: Microbiome; Urinary; Urinary Tract Infection; Age; Gender.
  • Naliboff BD, Locke K Jr, Schrepf D, Griffith JW, Moldwin R, Krieger JN, Rodriguez LV, Stephens-Shields AJ, Clemens JQ, Lai HH, Sutcliffe S, Taple BJ, Williams D, Pontari MA, Mullins C, Landis JR; MAPP Research Network. Reliability and validity of pain and urinary symptom severity assessment in urologic chronic pelvic pain; A MAPP Network Analysis. J Urol. 2022 Jun;207(6):1246-1255. doi: 10.1097/JU.0000000000002438. Epub 2022 Jan 21. [PMID: 35060778] [PMC10494963]
    Keywords: cystitis, interstitial; lower urinary tract symptoms; pelvic pain; prostatitis.
  • Naliboff BD, Schrepf AD, Stephens-Shields AJ, Clemens JQ, Pontari MA, Labus J, Taple BJ, Rodriguez LV, Strachan E, Griffith JW. Temporal relationships between pain, mood and urinary symptoms in urological chronic pelvic pain syndrome: A MAPP Network Study. J Urol. 2021 Jun;205(6):1698-1703. doi: 10.1097/JU.0000000000001595. Epub 2021 Feb 4. [PMID: 33535797] [PMC9179931]
    Keywords: cystitis, interstitial; lower urinary tract symptoms; pain; pelvic pain; prostatitis.

  • Roy R, Stephens AJ, Daisy C, Merritt L, Newcomb CW, Yang J, Dagher A, Curatolo A, Sachdev M, McNeish B, Landis R, van Bokhoven A, El-Hayek A, Froehlich J, Pontari MA, Zurakowski D, Lee RS, Moses MA. Association of longitudinal changes in symptoms and urinary biomarkers in patients with urological chronic pelvic pain syndrome: A MAPP Research Network Study. J Urol. 2021 Feb;205(2):514-523. doi: 10.1097/JU.0000000000001391. Epub 2020 Oct 7. [PMID: 33026902] [PMC8139408]
    Keywords: lipocalin-2; matrix metalloproteinases; pelvic pain; vascular endothelial growth factor; vascular endothelial growth factor receptor.

  • Clemens JQ, Stephens-Shields AJ, Newcomb C, Rodriguez LV, Lai HH, Bradley CS, Naliboff BD, Griffith JW, Taple BJ, Gupta P, Afari N, Harte SE, Strachan E, Guo W, Landis JR. Correlates of 1-year change in quality of life in patients with urologic chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. J Urol. 2020 Oct;204(4):754-759. doi: 10.1097/JU.0000000000001080. Epub 2020 Apr 15. [PMID: 32294397] [PMC7483873]
    Keywords: cystitis; interstitial; prostatitis.
  • Robles MTS, Cantalupo PG, Duray AM, Freeland M, Murkowski M, van Bokhoven A, Stephens-Shields AJ, Pipas JM, Imperiale MJ. Analysis of viruses present in urine from patients with interstitial cystitis. Virus Genes. 2020 Aug;56(4):430-438. doi: 10.1007/s11262-020-01767-z. Epub 2020 May 23. [PMID: 32447589] [PMC7339973]
    Keywords: Interstitial cystitis; NGS; PCR; Polyomavirus; Virus discovery.
  • Clemens JQ, Kutch JJ, Mayer EA, Naliboff BD, Rodriguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Clauw DJ, Harte SE, Schrepf AD, Williams DA, Andriole GL, Lai HH, Buchwald D, Lucia MS, van Bokhoven A, Mackey S, Moldwin RM, Pontari MA, Stephens-Shields AJ, Mullins C, Landis JR. The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS). Neurourol Urodyn. 2020 Aug;39(6):1803-1814. doi: 10.1002/nau.24423. Epub 2020 Jun 23. [PMID: 32578257] [PMC8025696]
    Keywords: chronic; interstitial cystitis; plasma biomarkers; prostatitis; urine biomarkers; urological chronic pelvic pain syndromes.
  • Nickel JC, Stephens A, Landis JR, Mullins C, van Bokhoven A, Anger JT, Ackerman AL, Kim J, Sutcliffe S, Krol JE, Sen B, Hammond J, Ehrlich GD; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Urinary fungi associated with urinary symptom severity among women with interstitial cystitis/bladder pain syndrome (IC/BPS). World J Urol. 2020 Feb;38(2):433-446. doi: 10.1007/s00345-019-02764-0. Epub 2019 Apr 26. [PMID: 31028455] [PMC6815247]
    Keywords: Bladder pain syndrome; Flares; Fungal; Interstitial cystitis; Mycobiome.
  • Afari N, Buchwald D, Clauw D, Hong B, Hou X, Krieger JN, Mullins C, Stephens-Shields AJ, Gasperi M, Williams DA; MAPP Research Network. A MAPP network case-control study of urological chronic pelvic pain compared with nonurological pain conditions. Clin J Pain. 2020 Jan;36(1):8-15. doi: 10.1097/AJP.0000000000000769. Epub 2019 Sep 26. [PMID: 31794439] [PMC7055954]
    Keywords: catastrophizing, chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, pelvic pain.
  • Nickel JC, Stephens-Shields AJ, Landis JR, Mullins C, van Bokhoven A, Lucia MS, Henderson JP, Sen B, Krol JE, Ehrlich GD; MAPP Research Network. A culture-independent analysis of the microbiota of female interstitial cystitis/bladder pain syndrome participants in the MAPP Research Network. J Clin Med. 2019 Mar 26;8(3):415. doi: 10.3390/jcm8030415. [PMID: 30917614] [PMC6462969]
    Keywords: bladder pain syndrome; infection; interstitial cystitis; microbiome; microbiota.
  • Rodríguez LV, Stephens AJ, Clemens JQ, Buchwald D, Yang C, Lai HH, Krieger JN, Newcomb C, Bradley CS, Naliboff B; MAPP Research Network. Symptom duration in patients with urologic chronic pelvic pain syndrome is not associated with pain severity, nonurologic syndromes and mental health symptoms: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Network Study. Urology. 2019 Feb;124:14-22. doi: 10.1016/j.urology.2018.11.015. Epub 2018 Nov 16. [PMID: 30452963] [PMC7037673]
    Keywords: chronic pain; mental disorders; pain measurement; pelvic pain; severity of illness index; symptom assessment.
  • Schrepf A, Naliboff B, Williams DA, Stephens-Shields AJ, Landis JR, Gupta A, Mayer E, Rodriguez LV, Lai H, Luo Y, Bradley C, Kreder K, Lutgendorf SK; MAPP Research Network. Adverse childhood experiences and symptoms of urologic chronic pelvic pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med. 2018 Sep 13;52(10):865-877. doi: 10.1093/abm/kax060. [PMID: 30212850] [PMC6135957]
    Keywords: Interstitial Cystitis/Painful Bladder Syndrome; Chronic Prostatitis with Chronic Pelvic Pain Syndrome; Psychological Trauma; Sexual Abuse.
  • Clemens JQ, Stephens-Shields A, Naliboff BD, Lai HH, Rodriguez L, Krieger JN, Williams DA, Kusek JW, Landis JR; MAPP Research Network. Correlates of health care seeking activities in patients with urological chronic pelvic pain syndromes: findings from the MAPP Cohort. J Urol. 2018 Jul;200(1):136-140. doi: 10.1016/j.juro.2017.12.055. Epub 2018 Jan 4. [PMID: 29307682] [PMC6002941]
    Keywords: cystitis; interstitial; patient acceptance of health care; pelvic pain; prostate; urinary bladder.
  • Sutcliffe S, Jemielita T, Lai HH, Andriole GL, Bradley CS, Clemens JQ, Gallop R, Hooton TM, Kreder KJ, Krieger JN, Kusek JW, Labus J, Lucia MS, Mackey S, Naliboff BD, Robinson NA, Rodriguez LV, Stephens-Shields A, van Bokhoven A, Wolin KY, Yan Y, Yang CC, Landis JR, Colditz GA; MAPP Research Network. A case-crossover study of urological chronic pelvic pain syndrome flare triggers in the MAPP Research Network. J Urol. 2018 May;199(5):1245-1251. doi: 10.1016/j.juro.2017.12.050. Epub 2017 Dec 27. [PMID: 29288643] [PMC5911194]
    Keywords: cystitis; interstitial; prostatitis; surveys and questionnaires; symptom flare up; urinary bladder.
  • Naliboff BD, Stephens AJ, Lai HH, Griffith JW, Clemens JQ, Lutgendorf S, Rodriguez LV, Newcomb C, Sutcliffe S, Guo W, Kusek JW, Landis JR; MAPP Research Network. Clinical and psychosocial predictors of urological chronic pelvic pain symptom change in 1 year: a prospective study from the MAPP Research Network. J Urol. 2017 Oct;198(4):848-857. doi: 10.1016/j.juro.2017.05.065. Epub 2017 May 18. [PMID: 28528930] [PMC5720154]
    Keywords: cystitis; interstitial; pelvic pain; prostate; prostatitis; urinary bladder.
  • Dagher A, Curatolo A, Sachdev M, Stephens AJ, Mullins C, Landis JR, van Bokhoven A, El-Hayek A, Froehlich JW, Briscoe AC, Roy R, Yang J, Pontari MA, Zurakowski D, Lee RS, Moses MA; MAPP Research Network. Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int. 2017 Jul;120(1):130-142. doi: 10.1111/bju.13832. Epub 2017 Apr 11. [PMID: 28263447] [PMC5951631]
    Keywords: Lipocalin 2 (also known as NGAL); Multidisciplinary Approach to the Study of Chronic Pelvic Pain; matrix metalloproteinase; neutrophil gelatinase associated lipocalin; vascular endothelial growth factor; vascular endothelial growth factor receptor 1.
  • Kutch JJ, Labus JS, Harris RE, Martucci KT, Farmer MA, Fenske S, Fling C, Ichesco E, Peltier S, Petre B, Guo W, Hou X, Stephens AJ, Mullins C, Clauw DJ, Mackey SC, Apkarian AV, Landis JR, Mayer EA; MAPP Research Network. Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain. 2017 Jun;158(6):1069-1082. doi: 10.1097/j.pain.0000000000000886. [PMID: 28328579] [PMC5435510]
    Keywords: Neuroimaging; Prediction; Chronic pain; Urologic pain.
  • Stephens-Shields AJ, Clemens JQ, Jemielita T, Farrar J, Sutcliffe S, Hou X, Landis JR; MAPP Research Network. Symptom variability and early symptom regression in the MAPP study: a prospective study of urological chronic pelvic pain syndrome. J Urol. 2016 Nov;196(5):1450-1455. doi: 10.1016/j.juro.2016.04.070. Epub 2016 Apr 27. [PMID: 27131464] [PMC5069105]
    Keywords: cystitis; epidemiologic research design; interstitial; pain; prostate; symptom assessment.
  • Parker KS, Crowley JR, Stephens-Shields AJ, van Bokhoven A, Lucia MS, Lai HH, Andriole GL, Hooton TM, Mullins C, Henderson JP. Urinary metabolomics identifies a molecular correlate of interstitial cystitis/bladder pain syndrome in a multidisciplinary approach to the study of chronic pelvic pain (MAPP) research network cohort. EBioMedicine. 2016 May;7:167-74. doi: 10.1016/j.ebiom.2016.03.040. Epub 2016 Mar 31. [PMID: 27322470] [PMC4909380]
    Keywords: biomarkers; cystitis; interstitial; mass spectrometry; pain measurement; steroids; steroids/urine; sulfates; sulfates/urine.
  • Griffith JW, Stephens-Shields AJ, Hou X, Naliboff BD, Pontari M, Edwards TC, Williams DA, Clemens JQ, Afari N, Tu F, Lloyd RB, Patrick DL, Mullins C, Kusek JW, Sutcliffe S, Hong BA, Lai HH, Krieger JN, Bradley CS, Kim J, Landis JR. Pain and urinary symptoms should not be combined into a single score: psychometric findings from the MAPP Research Network. J Urol. 2016 Apr;195(4 Pt 1):949-54. doi: 10.1016/j.juro.2015.11.012. Epub 2015 Nov 14. [PMID: 26585679] [PMC4867140]
    Keywords: chronic pain; cystitis, interstitial; factor analysis, statistical; prostatitis; urinary bladder.
  • Nickel JC, Stephens A, Landis JR, Mullins C, van Bokhoven A, Lucia MS, Ehrlich GD; MAPP Research Network. Assessment of the lower urinary tract microbiota during symptom flare in women with urologic chronic pelvic pain syndrome: A MAPP Network Study. J Urol. 2016 Feb;195(2):356-62. doi: 10.1016/j.juro.2015.09.075. Epub 2015 Sep 26. [PMID: 26410734] [PMC4770794]
    Keywords: cystitis; infection; interstitial; microbiota; symptom assessment.
  • Nickel JC, Stephens A, Landis JR, Chen J, Mullins C, van Bokhoven A, Lucia MS, Melton-Kreft R, Ehrlich GD; MAPP Research Network. Search for microorganisms in men with urologic chronic pelvic pain syndrome: a culture-independent analysis in the MAPP Research Network. J Urol. 2015 Jul;194(1):127-35. doi: 10.1016/j.juro.2015.01.037. Epub 2015 Jan 14. [PMID: 25596358] [PMC4475477]
    Keywords: chronic pain; infection; microbiota; pelvic pain; prostatitis.
  • Naliboff BD, Stephens AJ, Afari N, Lai H, Krieger JN, Hong B, Lutgendorf S, Strachan E, Williams D; MAPP Research Network. Widespread psychosocial difficulties in men and women with urologic chronic pelvic pain syndromes: case-control findings from the multidisciplinary approach to the study of chronic pelvic pain research network. Urology. 2015 Jun;85(6):1319-27. doi: 10.1016/j.urology.2015.02.047. [PMID: 26099876] [PMC4479402]
    Keywords: chronic pain; pelvic pain; severity of illness index; urologic diseases.
  • Clemens JQ, Clauw DJ, Kreder K, Krieger JN, Kusek JW, Lai HH, Rodriguez L, Williams DA, Hou X, Stephens A, Landis JR; MAPP Research Network. Comparison of baseline urological symptoms in men and women in the MAPP research cohort. J Urol. 2015 May;193(5):1554-8. doi: 10.1016/j.juro.2014.11.016. Epub 2014 Nov 13. [PMID: 25463989] [PMC4454891]
    Keywords: chronic pain; cystitis; interstitial; pelvic pain; prostatitis.
  • Krieger JN, Stephens AJ, Landis JR, Clemens JQ, Kreder K, Lai HH, Afari N, Rodríguez L, Schaeffer A, Mackey S, Andriole GL, Williams DA; MAPP Research Network. Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study. J Urol. 2015 Apr;193(4):1254-62. doi: 10.1016/j.juro.2014.10.086. Epub 2014 Oct 22. [PMID: 25444992] [PMC4497586]
    Keywords: cystitis; female; interstitial; male; questionnaires; urinary bladder.